What Is Ketamine Therapy?

Ketamine has been used in medicine for decades as an anesthetic, but research has shown that at lower, controlled doses it can rapidly reduce symptoms of depression, suicidal ideation, and anxiety. Unlike SSRIs, which may take weeks to take effect, ketamine can provide improvements within hours to days.

Ketamine Infusion Therapy

How it works:

• Administered intravenously in a clinical setting.
• Doses are carefully tailored to the individual.
• A series of sessions are typically recommended.

Benefits:

• Rapid relief from depression and suicidal thoughts.
• May improve symptoms of PTSD, anxiety, and OCD.
• Customizable dosing.

Considerations:

• Requires IV administration.
• Not FDA-approved for depression (used off-label).
• Must be done in a safe, monitored medical environment.

Spravato® (Esketamine Nasal Spray)

How it works:

• FDA-approved in 2019 for treatment-resistant depression and major depressive disorder with suicidal thoughts.
• Administered in a clinic under supervision.
• Taken alongside an oral antidepressant.

Benefits:

• Backed by FDA approval.
• Non-invasive (nasal spray vs. IV).
• Covered by many insurance plans.

Considerations:

• Requires 2+ hours of monitoring after each dose.
• Typically given twice weekly for the first month, then tapered.
• Not a standalone treatment—must be combined with an oral antidepressant.

Which Option Is Right for You?

Both ketamine infusion therapy and Spravato® can be effective, but the right choice depends on factors like:

• Insurance coverage
• Medical history
• Comfort with IV vs. nasal spray
• Diagnosis and severity of symptoms

Consulting with a mental health provider experienced in ketamine treatments is the best way to determine which approach may benefit you.

Final Thoughts

Ketamine therapy—whether through IV infusion or Spravato® nasal spray—represents a promising step forward for those struggling with depression, anxiety, PTSD, and other mental health challenges. If you’ve tried traditional treatments without success, these innovative options may offer the breakthrough you’ve been searching for.